The System
The CytoViva Hyperspectral Imaging System (HSI) provides spectral quantification of materials and biologicals imaged with the CytoViva Nano-scale Optical Microscope. Operating in the visible near infrared spectral range (VNIR), CytoViva HSI supports research in areas such as nano-drug delivery and nano-toxicology. This spectral quantification method supports both non-fluorescent and fluorescently labeled components in live cells and nano-materials.
In each application, the CytoViva Nano-scale Microscope and Hyperspectral Imaging Systems work together as a seamless solution to provide analytical confirmation of nano-scale materials and their interactions with biologicals or other composite materials.
CytoViva HSI combines the following primary components:
- A concentric imaging spectrophotometer containing original, aberration-corrected convex holographic diffraction gratings. Operating in the 400-1,000nm spectral range, this patented spectrophotometer technology provides superior signal-to-noise ratio insuring that only spectra from the high contrast CytoViva microscope image is captured for analysis.
- Customized hyperspectral image analysis software specifically designed to support microscopy applications. This proprietary software is a modified version of the ITT ENVI hyperspectral image analysis system. As a data collection and reporting capability, this software is easy to use and highly intuitive. Using this system, spectral analysis can be performed within a user defined region of interest down to the pixel level. With the ability to perform "spectral un-mixing," this software enables delineation of different elements within the sample by subtraction of unwanted spectra within a region of interest.
- A motorized stage, integrated onto the CytoViva microscope system, acts as a "push broom", moving the sample precisely over the hyperspectral image detector field of view. Operation of this push broom capability is integrated into the image analysis software system.
While this system was specifically designed to support nanoscale studies, it also supports a wide range of bio-medical research initiatives in areas such as cell biology and infectious disease.
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